Year: 2023 | Month: October | Volume 13 | Issue 5
Management of Subclinical Endometritis by Immunomodulators and Proteolytic Enzymes
Vinay Kumar Manjhi
Nitin Kumar Bajaj*
Suresh Prasad Shukla and Pratipal Singh Kaurav
DOI:10.30954/2277-940X.05.2023.10
Abstract:
Five hundred repeat breeder cows (2-4 parity) were randomly selected from livestock farm, Kuthuliya and villages of Rewa (M.P.). On the basis of endometrial cytology by cytobrush technique 140 repeat breeder cows (28%) were diagnosed to be suffering from subclinical endometritis. Out of the animals found positive 30 cows were selected and were divided into 5 groups (n=06 per group). The group wise treatment allotted were Group I- Levamisole, 2.5 mg/kg body weight, once for three weeks, S/c; Group II- 100 µgm E. coli LPS in 30 ml PBS, single I/U infusion; Group III- 500 mg Benzathine cephapirin, single I/U infusion; Group IV- Proteolytic enzymes in 10 ml distilled water, single I/U infusion and Group V (Control)-no treatment. All the animals were subjected to endometrial cytology at 12 hrs., 24 hrs. and 48 hrs. post-treatment. The animals were bred at next successive oestrus and pregnancy was confirmed 60 days post insemination. Endometrial cytology in treatment group I revealed that the PMN per cent increased significantly (p<0.05) from 0 hrs. to 24 hrs. In groups II, III and IV, the increase in PMN per cent was significant (p<0.05) from 0 hrs. to 48 hrs. The overall pregnancy rate was higher (83.33%) in treatment groups II and IV as compared to treatment group III (50.00%), group I (33.33%) and group V (0.00%), respectively. It was concluded that immunomodulators like E. coli lipopolysaccharide and proteolytic enzymes proved to be better for enhancing uterine immunity and pregnancy rates in subclinical endometritic repeat breeder cows.
Highlights
- Significant increase in PMN percentage was observed in all treatment groups from post-treatment 0 hrs. to 24 hrs.
- First service pregnancy rates were higher in group IV (proteolytic enzymes group).
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